Unusual Presentation of Stevens-Johnson Syndrome Induced by Trimethoprim-Sulfamethoxazole: A Case Report

Stevens-Johnson syndrome (SJS) is a severe and potentially life-threatening adverse drug reaction characterized by mucocutaneous lesions. Here, I present a unique case of SJS induced by trimethoprim-sulfamethoxazole (TMP-SMX) with an unusual clinical presentation. A 45-year-old female patient with a history of urinary tract infection presented with the development of widespread erythematous macules and papules, progressing to blisters and erosions involving the oral mucosa. The patient's condition rapidly deteriorated, necessitating intensive care management. The temporal association between TMP-SMX initiation and the onset of symptoms, the characteristic clinical and histopathological findings supported the diagnosis of SJS. Prompt withdrawal of the offending drug, supportive care, and multidisciplinary management resulted in a favorable outcome for the patient.