MAIN WORLD TRENDS IN OBTAINING ARABINOGALACTAN, DIHYDROQUERCETIN FROM LARCH WOOD

The paper presents the main results of patent research on methods of preparation of arabinogalactan and dihydroquercetin used in the world practice. The interest to this problem is connected with unique biological properties of these biologically active additives. A patent search with the depth of 25 years was carried out. The leading position of inventors from the Russian Federation, who own 77% of patents, was established. The research peaks are given and information about the leading patent holders is given. 3 main directions of Siberian larch processing are established: AG extraction, DKV and complex methods of processing. It is revealed that the inventors of the Russian Federation give preference to obtaining AG by precipitation of the target product in an organic solvent. To a lesser extent, the filtration method with separation of the target product by spray drying is used. Methods of obtaining AGW are presented in two patents. Complex methods of wood processing make it possible to obtain along with bioflavonoids (BFV) and oligosaccharides (including AG) and technical products: wood resins, oils, etc., as well as biosolids and oligosaccharides (including AG). Of great interest are patented sulfated derivatives of AG, which have anticoagulant and hypolipidemic activity and can become an alternative to heparin. Foreign authors (mainly from China) patent compositions of AG with biologically active components, which makes it possible to obtain products with therapeutic and prophylactic effect. In some inventions of authors from the PRC, sulfated AG is also patented. Some inventors from the USA patent methods in which purified AG and its modifications act as carriers for delivery of therapeutic agent to cell receptors, which corresponds to the principle of targeted drug delivery, which has recently become dominant.