A Self-Activating IL-15 Chimeric Cytokine Receptor to Empower Cancer Immunotherapy
Our data suggest that the tethering of IL-15 to its receptor IL2Rβ empowers NK cell cytolytic activity. Additionally, the tethering of IL-15 will prevent any systemic risk of toxicity.
Authors
- Haitao Zhu (ORCID: https://orcid.org/0000-0002-4168-4053)
- Sumei Chen
- Lingrong Yang (ORCID: https://orcid.org/0000-0003-3042-0113)
- Bing Xia (ORCID: https://orcid.org/0000-0002-9178-5493)
- Youssef Jounaïdi (ORCID: https://orcid.org/0000-0001-6077-0646)
- Zheng-Hao Piao
Institutions
- Harvard University (US)
- Guiyang Medical University (CN)
- Hangzhou Normal University (CN)
- Massachusetts General Hospital (US)
- Affiliated Hospital of Guizhou Medical University (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/itt.s490498
- Citations
- 7
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.68