Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited
Among relatively lean Chinese adults, higher genetically predicted BMI was associated with higher risks of incident CVDs. Excess mortality risks at lower BMI in conventional analyses are likely not causal and may reflect residual reverse causality.
Authors
- Iain Turnbull (ORCID: https://orcid.org/0000-0002-9913-1961)
- Qilian Jiang
- Sam Morris
- Shihao You
- Paul Sherliker (ORCID: https://orcid.org/0009-0003-9559-6029)
- Mohsen Mazidi (ORCID: https://orcid.org/0000-0003-3059-229X)
- Haiqiang Qin (ORCID: https://orcid.org/0000-0003-4500-7508)
- Fengxia Qu
- Kun Fang (ORCID: https://orcid.org/0009-0003-2943-147X)
- Hao Wang (ORCID: https://orcid.org/0000-0003-4807-3172)
- Chen Hu
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Yuelong Huang (ORCID: https://orcid.org/0009-0005-8372-2352)
- Andri Iona (ORCID: https://orcid.org/0000-0001-8042-9672)
- Shuya Li (ORCID: https://orcid.org/0000-0001-5320-8452)
- Gang Zhou (ORCID: https://orcid.org/0000-0002-1533-7795)
- Pek Kei Im (ORCID: https://orcid.org/0000-0002-2624-9766)
- Mingyuan Zou (ORCID: https://orcid.org/0000-0001-6140-981X)
- Xiao Han (ORCID: https://orcid.org/0000-0003-1707-5079)
- Zammy Fairhurst-Hunter
- Jinyan Chen (ORCID: https://orcid.org/0000-0003-4103-7056)
- Fiona Bragg (ORCID: https://orcid.org/0000-0002-9181-6886)
- Zengchang Pang (ORCID: https://orcid.org/0000-0003-4746-0074)
- Xiaojiu Li
- Jianrong Jin Fang Liu
- Caixia Dong (ORCID: https://orcid.org/0000-0002-6353-7273)
- Xiaohuan Wang (ORCID: https://orcid.org/0000-0002-2425-8220)
- Johnathan Clarke
- Ziyan Guo (ORCID: https://orcid.org/0000-0001-7745-3073)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Enke Mao
- Dan Schmidt (ORCID: https://orcid.org/0000-0003-0704-8165)
- Xin Cheng (ORCID: https://orcid.org/0000-0002-2598-8380)
- Kuang Lin (ORCID: https://orcid.org/0000-0002-7360-3385)
- Jinyi Zhou (ORCID: https://orcid.org/0000-0001-6057-862X)
- Yulu Qin (ORCID: https://orcid.org/0000-0001-9300-0445)
- Rajani Sohoni
- Xukui Zhang
- Richard Peto (ORCID: https://orcid.org/0000-0001-8219-5339)
- Robert Clarke (ORCID: https://orcid.org/0000-0002-9802-8241)
- Alfred Pozarickij (ORCID: https://orcid.org/0000-0002-6937-8496)
- Zhanling Liao
- Xiaodi Zhao (ORCID: https://orcid.org/0000-0002-1817-803X)
- Xun Wang (ORCID: https://orcid.org/0000-0002-7808-7543)
- Chen Wang (ORCID: https://orcid.org/0000-0003-4055-7391)
- Yilei Li (ORCID: https://orcid.org/0000-0002-9786-1127)
- Ruying Hu (ORCID: https://orcid.org/0000-0002-5917-3454)
- Pang Yao (ORCID: https://orcid.org/0000-0002-6875-7435)
- Xianping Wu
- Liang Cheng (ORCID: https://orcid.org/0000-0002-6665-6710)
- Yinghua Chen (ORCID: https://orcid.org/0000-0001-6295-7068)
- Hannah Fry (ORCID: https://orcid.org/0009-0006-1584-2042)
- Quan Kang (ORCID: https://orcid.org/0000-0001-8598-1984)
- Qiang Dong (ORCID: https://orcid.org/0009-0009-2730-0752)
- Christiana Kartsonaki (ORCID: https://orcid.org/0000-0002-3981-3418)
- Maria Kakkoura (ORCID: https://orcid.org/0000-0003-3688-1367)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Ningyu Chen
- Peiling Chen (ORCID: https://orcid.org/0000-0001-7228-2690)
- Yulian Gao
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Saredo Said
- Mingqiang Li (ORCID: https://orcid.org/0000-0002-5178-4138)
- Jinping Jiang
- Ruth Boxall (ORCID: https://orcid.org/0000-0003-0356-3549)
- Xiaojia Sun
- Aiyu Tang
- Naying Chen
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Feifei Li (ORCID: https://orcid.org/0000-0001-7159-5775)
- Xuefeng Yang
- Jianguo Li (ORCID: https://orcid.org/0000-0002-2251-8308)
- Neil Wright (ORCID: https://orcid.org/0000-0002-3946-1870)
- Sarah Parish (ORCID: https://orcid.org/0000-0003-3532-0832)
- Qunhua Nie
- Jing Ding (ORCID: https://orcid.org/0000-0001-5135-4210)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Shukuan Wu
- Liuping Wei
- Sam Sansome
- Xue Zhou (ORCID: https://orcid.org/0000-0002-9365-5887)
- Jiaqiu Liu
- Chaojun Gua
- Jie Yang (ORCID: https://orcid.org/0009-0007-2650-3254)
- Xin Fu (ORCID: https://orcid.org/0009-0001-7478-0244)
- Haiyan Gou
- Shixian Feng
- Yi Dong
- Zhongxi Fu (ORCID: https://orcid.org/0000-0002-4965-908X)
- Dejiang Ji
- Yongmei Liu (ORCID: https://orcid.org/0000-0002-8864-1317)
- Yu An
- Qiling Chen (ORCID: https://orcid.org/0000-0001-6702-1998)
- Tianyou He (ORCID: https://orcid.org/0000-0002-7300-2539)
- Xiaocao Tian (ORCID: https://orcid.org/0000-0002-4275-3719)
- Bo Yu (ORCID: https://orcid.org/0000-0003-4689-9341)
- Ahmed Edris Mohamed
- Xunfu Zhong
- Yaoming Zhai
- Rory Collins (ORCID: https://orcid.org/0000-0001-8288-8602)
- Naixin Jv
- Liangcai Ma
- Xiaohui Sun (ORCID: https://orcid.org/0009-0006-2964-4768)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6028-2554)
- Xin Wang (ORCID: https://orcid.org/0000-0002-0322-8970)
- Zhihong Liu (ORCID: https://orcid.org/0000-0002-7988-3787)
- Libo Zhang (ORCID: https://orcid.org/0000-0002-2972-5174)
- Chao Liu (ORCID: https://orcid.org/0000-0001-8683-3473)
- Ran Tao (ORCID: https://orcid.org/0000-0002-9962-1768)
- Lei Fan (ORCID: https://orcid.org/0000-0002-6157-7167)
- Yiping Chen (ORCID: https://orcid.org/0000-0003-0685-2127)
- Hao Zhang (ORCID: https://orcid.org/0009-0009-9322-0048)
- Lin Wang (ORCID: https://orcid.org/0000-0002-9370-6891)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-2095-5261)
- Feng Liu (ORCID: https://orcid.org/0000-0002-3570-4222)
- Yongjun Wang (ORCID: https://orcid.org/0000-0001-9883-2099)
- Xi Zhang (ORCID: https://orcid.org/0000-0001-9344-6471)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-7630-8162)
- Jingyi Liu (ORCID: https://orcid.org/0000-0002-8079-655X)
- Tao Wang (ORCID: https://orcid.org/0000-0002-9647-5718)
- Liming Zhang (ORCID: https://orcid.org/0000-0002-0990-7042)
- Yanmei Zhu
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Xiaoting Li (ORCID: https://orcid.org/0000-0003-1211-9132)
- Zilong Hao (ORCID: https://orcid.org/0000-0002-9754-4447)
- Xiaofang Chen (ORCID: https://orcid.org/0000-0002-2973-0432)
- Duo Liu (ORCID: https://orcid.org/0000-0002-0674-0558)
- Yanjie Li (ORCID: https://orcid.org/0000-0002-9545-6179)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Huilin Liu (ORCID: https://orcid.org/0000-0002-8455-8321)
- Junzheng Wang (ORCID: https://orcid.org/0000-0002-7635-9461)
- Sisi Wang (ORCID: https://orcid.org/0000-0001-7156-8486)
- Liang Cheng (ORCID: https://orcid.org/0000-0003-1635-2732)
- Shanshan Zhou (ORCID: https://orcid.org/0000-0003-1689-0266)
- Shaojie Wang (ORCID: https://orcid.org/0000-0002-2786-519X)
- Jian Su (ORCID: https://orcid.org/0009-0004-7361-4449)
- Zhendong Guo (ORCID: https://orcid.org/0000-0001-7708-4183)
- Yulan Zhu
- Jian Lan
- Wan Meng (ORCID: https://orcid.org/0000-0002-4675-1577)
- Xiaomo Du
- Pengfei Ge (ORCID: https://orcid.org/0000-0002-9270-4106)
- Junshi Chen (ORCID: https://orcid.org/0000-0001-5530-1343)
- Wei Hou (ORCID: https://orcid.org/0000-0002-7208-7243)
- Lirong Jin (ORCID: https://orcid.org/0000-0002-4767-3574)
- Ling Yang (ORCID: https://orcid.org/0000-0002-5506-7021)
- Weiwei Gong (ORCID: https://orcid.org/0000-0002-7066-4772)
- Liming Li (ORCID: https://orcid.org/0000-0002-2898-6188)
- Liyuan Zhou (ORCID: https://orcid.org/0000-0002-8636-9217)
- Zhongxiao Li (ORCID: https://orcid.org/0000-0002-5836-6406)
- Peng Du (ORCID: https://orcid.org/0000-0003-1077-5638)
- Shumei Ma (ORCID: https://orcid.org/0009-0009-1364-8256)
- Yujie Hua (ORCID: https://orcid.org/0009-0007-7879-1681)
- Yun Liu (ORCID: https://orcid.org/0000-0002-7734-8078)
- Ka Hung Chan (ORCID: https://orcid.org/0000-0002-6958-9349)
- Weizhi Wang (ORCID: https://orcid.org/0000-0002-9069-6982)
- Liyang Liu (ORCID: https://orcid.org/0000-0002-6868-319X)
- Jingchao Liu (ORCID: https://orcid.org/0000-0002-7102-8823)
- Hongyuan Chen (ORCID: https://orcid.org/0000-0003-4650-0791)
- Xuecheng Yang (ORCID: https://orcid.org/0000-0002-3607-9887)
- Chunmei Wang (ORCID: https://orcid.org/0000-0003-0826-6762)
- Lingli Chen (ORCID: https://orcid.org/0009-0000-4575-690X)
- Xiaoming Yang (ORCID: https://orcid.org/0000-0003-2482-8673)
- Jian Xu (ORCID: https://orcid.org/0000-0001-7303-2909)
- Ding Zhang
- Yin Li (ORCID: https://orcid.org/0009-0007-6081-5067)
- Ming Wu (ORCID: https://orcid.org/0000-0003-0895-9235)
- Xiaolan Ren
- Weiwei Zhou (ORCID: https://orcid.org/0000-0003-2003-7743)
- Biyun Chen (ORCID: https://orcid.org/0000-0002-4672-5643)
- Huimei Li (ORCID: https://orcid.org/0000-0003-2608-0283)
- Xiaoyi Zhang (ORCID: https://orcid.org/0009-0001-7015-4158)
- Fanwen Meng (ORCID: https://orcid.org/0000-0002-1608-4056)
- Xiaona Xing
- Mike Hill
- Yihe Hu
- Jinhuai Meng
- Pan He
- Yu‐Mei Chang (ORCID: https://orcid.org/0000-0001-6388-9626)
- Alex Hacker
- Shanpeng Li
- Deren Wang (ORCID: https://orcid.org/0000-0002-2388-3585)
- Michael V. Holmes
- Ruqin Gao
- Hua Zhang (ORCID: https://orcid.org/0009-0000-1024-6408)
- Can Hou
- Yonglin Zhou
- Paul Ryder
- Ningmei Zhang
- Qingmei Xia
- Min Weng
- Yan Lu
- Shichun Yan
- Qiaohua Xu (ORCID: https://orcid.org/0000-0002-7974-6125)
- Liang Chang (ORCID: https://orcid.org/0000-0002-7417-1799)
- Qiang Sun
- Ximin Hu
- Dongxia Pan
- Xiaoli Cheng
- Kaixu Xie
- Simon Gilbert
- Guojin Luo
- Qinai Xu
- Feng Ning
- Yueshi Mao
- Lihua Zhang Xiaohong Chen
- Ming Liu
- Xin Xu
- Qijun Gu
- Huarong Sun
- Wenwen Yuan (ORCID: https://orcid.org/0009-0005-7670-7234)
- Zhenzhu Tang (ORCID: https://orcid.org/0000-0002-2352-2616)
- Huajun Long (ORCID: https://orcid.org/0000-0002-7489-3943)
- Rong Pan
- Yun Lu
- Lili Hui
- Robin Walters
- Chunning Feng
- Yiting Mao
- Becky Stevens
- Jihua Wang (ORCID: https://orcid.org/0009-0007-0996-1122)
- Lei Wang (ORCID: https://orcid.org/0009-0006-8680-3737)
- Ping Wang (ORCID: https://orcid.org/0000-0002-9922-5407)
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Peking University (CN)
- University of Oxford (GB)
- Health Data Research UK (GB)
- Qingdao Municipal Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- International Journal of Epidemiology
- Published
- 2024-08-14
- DOI
- https://doi.org/10.1093/ije/dyae125
- Citations
- 5
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Wellcome Trust
- Cancer Research UK
- British Heart Foundation
- Ministry of Science and Technology of the People's Republic of China
- Centers for Disease Control and Prevention
- Medical Research Council
- National Key Research and Development Program of China