Fluidic Properties of Diamond and SplitP Structures with Varying Porosity Levels in Tissue Engineering Applications: A Computational Fluid Dynamics Analysis

This study investigates the fluidic properties of the Diamond and SplitP structures with varying porosity levels (55%, 65%, and 75%) for tissue engineering applications using computational analysis. The scaffolds were designed using nTopology software and optimized to achieve the desired porosity and mechanical properties. The power law model was utilized to analyze blood as a non-Newtonian fluid. The study aims to optimize the scaffolds by observing fluidic characteristics such as permeability, pressure drop, and wall shear stress (WSS) to make them the optimal choice for bone tissue engineering applications. The results demonstrate that increasing porosity leads to higher permeability and lower pressure drop and WSS across the scaffolds. The findings suggest that the optimized Diamond and SplitP scaffolds with appropriate porosity levels can provide a suitable environment for cell adhesion, migration, proliferation, and differentiation, making them promising candidates for bone tissue engineering applications.