Rationale for antimicrobial activity of phytocomplexes recommended for use in oncological pathology

The modulation of the composition of the oral microbiome in cancer patients is a significant approach to preventing and managing complications from chemotherapy and radiation. The use of mouthwashes is the first treatment option to rehabilitate these patients. Aim: This study evaluated the characteristics of the impact of phytocomplexes on the dynamics of the formation of a mixed microbial consortium comprising potential agents of infectious complications of oncological processes. Methods: The work carried out an experimental assessment of the antimicrobial properties of the phytocomplexes ‘Mukosept’ and ‘Aphrodite’, by analyzing their influence on the consortium microbial group S. sanguis and F. nucleatum, using the infrastructure of the unique scientific installation “Transgenebank”. Results: Based on the results of the experiments, using the automatic programmable cultivation technique, differences in the development of the bacterial population were identified, considering the addition of the studied samples of phytocomplexes at different concentrations. It has been revealed that the phytocomplex ‘Mukosept’ exhibits a more evident antibacterial effect in comparison to the phytocomplex ‘Aphrodite’. Conclusion: Thus, the influence of phytocomplexes on the dynamics of the development of a mixed microbial consortium of potential pathogens of infectious complications of oncological processes has been determined.