Plasma amyloid beta biomarkers predict amyloid positivity and longitudinal clinical progression in mild cognitive impairment
Plasma amyloid beta (Aβ) biomarkers correlated with 11C-Pittsburgh compound B uptake, mainly in the frontal/parietotemporal cortices and posterior cingulate gyrus.The amyloid composite biomarker can predict amyloid positron emission tomography positivity with a high area under the curve of 0.943 in a community-based mild cognitive impairment cohort.The higher amyloid composite biomarker at baseline was significantly associated with worsening Mini-Mental State Examination score and a high risk for developing Alzheimer's disease (AD) dementia over 8 years.The amyloid composite biomarker can predict clinical progression to AD dementia with a high area under the curve of 0.860.Apolipoprotein E ε4 status influenced the plasma Aβ biomarker levels.
Authors
- Takuya Ataka (ORCID: https://orcid.org/0000-0001-9416-9867)
- Kenichi Yabuuchi
- Tsukasa Takeuchi (ORCID: https://orcid.org/0009-0008-9711-8377)
- Naoki Kaneko (ORCID: https://orcid.org/0000-0002-3579-7908)
- Shunya Hanai
- Teruaki Masuda (ORCID: https://orcid.org/0000-0001-9730-3339)
- Shinichi Iwamoto
- Takeshi Mizukami (ORCID: https://orcid.org/0000-0003-3335-2881)
- Noriyuki Kimura (ORCID: https://orcid.org/0000-0001-7137-7268)
- Yosuke Takeuchi (ORCID: https://orcid.org/0000-0001-6487-4610)
- Hideaki Tasai
- Etsuro Matsubara (ORCID: https://orcid.org/0009-0006-5150-1130)
- Temmei Ito (ORCID: https://orcid.org/0000-0001-5834-594X)
- Takehiko Miyagawa
Institutions
- Oita University (JP)
- Eisai (Japan) (JP)
- Shimadzu (Japan) (JP)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/trc2.70008
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science