Disorders of menstrual function during puberty and the risk of nonalcoholic fatty liver disease with comorbid diseases of the gastrointestinal tract

The aim of the study was to determine the relationship between disorders of menstrual function in adolescence and the risk of nonalcoholic fatty liver disease (NAFLD) with comorbid gastrointestinal pathology. Materials and methods. We examined 129 adolescent girls aged 12–17 years with menstrual disorders (61 with abnormal uterine bleeding (AUB) and 68 with oligomenorrhea (OM)) and measured anthropometrics, indices of lipid and carbohydrate metabolism and liver enzymes. Data are presented in the form of mean (M), standard deviation (SD) and median (Me), a factorial model was developed. Results. The study shows the peculiarities of the clinical course of menstrual function disorders in girls of puberty age. Patients with AUB were characterized by significantly lower average body mass indices, they were younger compared to patients with OM. The nature of metabolic changes that depended on the type of menstrual disorders in teenage girls was clarified. Adolescents with AUB had statistically significantly higher average levels of immunoreactive insulin, HOMA index, triglycerides, very low-density lipoprotein cholesterol, aspartate aminotransferase. This creates conditions for the formation of nonalcoholic fatty liver disease. A model was created regarding the participation of dyslipoproteinemia, changes in the carbohydrate spectrum and levels of liver enzymes in the formation of nonalcoholic fatty liver disease in girls with menstrual cycle disorders. Conclusions. Disorders of menstrual function are associated with an increased risk of NAFLD formation. Adolescent girls with menstrual disorders need metabolic screening. The atherogenic profile of lipoproteinemia, marked changes in the carbohydrate spectrum and increased serum levels of liver enzymes in girls with menstrual cycle disorders are the basis for the formation of nonalcoholic fatty liver disease.