Evaluation of the sedative-motor effects of novel GABAkine imidazodiazepines using quantitative observation techniques in rhesus monkeys
GABAkines with preferential efficacy at α2/α3GABA<sub>A</sub> and/or α5GABA<sub>A</sub> subtypes engendered sedative-motor effects in monkeys, although only compounds with α5GABA<sub>A</sub> activity engendered deep sedation. Moreover, the significant relationship between potency obtained with in vitro electrophysiology data and the rest/sleep posture measure suggests a role for the α5GABA<sub>A</sub> subtype in this milder form of sedation.
Authors
- Daniela Rüedi‐Bettschen
- James M. Cook (ORCID: https://orcid.org/0000-0001-5512-3022)
- Donna M. Platt
- Jaren A. Reeves-Darby (ORCID: https://orcid.org/0000-0001-5781-3991)
- James K. Rowlett (ORCID: https://orcid.org/0000-0002-4077-5017)
- Tanya Pareek (ORCID: https://orcid.org/0000-0001-9133-0811)
- Eliseu da Cruz Moreira-Junior
- Lalit K. Golani (ORCID: https://orcid.org/0000-0002-6233-7747)
- Farjana Rashid (ORCID: https://orcid.org/0000-0002-2052-2880)
- J. E. Cook (ORCID: https://orcid.org/0000-0002-1698-285X)
- Laís F. Berro (ORCID: https://orcid.org/0000-0003-4841-4117)
- Md Yeunus Mian (ORCID: https://orcid.org/0000-0002-7520-1750)
- Dishary Sharmin (ORCID: https://orcid.org/0000-0003-0417-4262)
Institutions
- West Virginia University Institute of Technology (US)
- University of Mississippi Medical Center (US)
- Center for Innovation (US)
- University of Wisconsin–Milwaukee (US)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1177/02698811241286760
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse
- National Institute of General Medical Sciences