<scp>TRPM8</scp> overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the <scp>RTP3</scp>/<scp>STAT3</scp> pathway
Our findings underscore the critical role of the TRPM8-RTP3-STAT3 axis in maintaining the malignant progression of HCC. Moreover, our study demonstrates that AD80 is involved in anti-tumour processes by upregulating the expression of TRPM8.
Authors
- Lichan Chen (ORCID: https://orcid.org/0000-0002-0838-776X)
- Liwen Zhu (ORCID: https://orcid.org/0000-0003-2169-186X)
- Dayong Gu (ORCID: https://orcid.org/0000-0002-9547-8474)
- Dongmei Gou
- Weihong Huang (ORCID: https://orcid.org/0000-0003-2443-1756)
- Nansong Xu
- Jianning Song
- Cheng Gao (ORCID: https://orcid.org/0000-0001-5549-1327)
- Yong Xu (ORCID: https://orcid.org/0000-0001-6755-6482)
- Mingqin Zhou
- Hongzhong Zhou
- Yue Zhu
- Haohua Zhang
- Yajun Zhang (ORCID: https://orcid.org/0009-0002-2437-7227)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Southern University of Science and Technology (CN)
- Shantou University (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- Guangdong Provincial People's Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/cam4.70109
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province