Oral Disease and Atherosclerosis May Be Associated with Overlapping Metabolic Pathways
The discovery of a common sphingomyelin metabolite in both disease processes is a novel finding suggesting that gingivitis and periodontitis may be associated with some overlapping metabolic pathways associated with ASCVD and indicating potential shared mechanisms among these diseases.Knowledge Transfer Statement:The same metabolites may be altered in atherosclerosis and oral disease. Specifically, a common sphingomyelin metabolite was inversely associated with gingivitis and carotid intima media thickness, a subclinical marker of atherosclerotic cardiovascular disease. These findings can provide valuable insights for future mechanistic studies to establish potential causal relationships, with the hope of influencing disease prevention and targeted early treatment.
Authors
- Lisa de las Fuentes (ORCID: https://orcid.org/0000-0002-4689-325X)
- Jubao Duan (ORCID: https://orcid.org/0000-0002-7215-3220)
- John R. Shaffer (ORCID: https://orcid.org/0000-0003-1897-1131)
- Steven E. Reís (ORCID: https://orcid.org/0000-0001-8023-0102)
- Anum Saeed (ORCID: https://orcid.org/0000-0003-1783-678X)
- Daniel W. McNeil (ORCID: https://orcid.org/0000-0002-0766-8455)
- Christopher G. McKennan
- Mary L. Marazita (ORCID: https://orcid.org/0000-0002-2648-2832)
- Mariana Bezamat (ORCID: https://orcid.org/0000-0001-9397-3167)
- Betsy Foxman (ORCID: https://orcid.org/0000-0001-6682-238X)
- Rui Zhou (ORCID: https://orcid.org/0000-0002-0782-4761)
- Dylan J. Baxter
- Haibo Liu (ORCID: https://orcid.org/0000-0002-4213-2883)
Institutions
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- University of Florida (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- JDR Clinical & Translational Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1177/23800844241280383
- Citations
- 5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Pennsylvania Department of Health
- National Institutes of Health
- National Heart, Lung, and Blood Institute