Preventive Medications in Pediatric Migraine
In this network meta-analysis of randomized clinical trials, topiramate and pregabalin were associated with reduction in headache frequency and intensity. Although there were also other drugs that showed statistically significant results (flunarizine, riboflavin, amitriptyline, and cinnarizine), more studies were required for a robust conclusion. None of the drugs were associated with improved quality of life or attack duration, underscoring the need for further research to develop more comprehensive treatment strategies and explore the potential of combination therapies, especially those involving vitamins. Future studies should focus on validating these findings and expanding the treatment landscape for pediatric migraine management.
Authors
- Omid Kohandel Gargari (ORCID: https://orcid.org/0000-0002-8182-0582)
- Niloofar Seighali (ORCID: https://orcid.org/0000-0002-8862-6029)
- Faraidoon Haghdoost (ORCID: https://orcid.org/0000-0003-3912-5874)
- Mansoureh Togha (ORCID: https://orcid.org/0000-0002-9368-6835)
- Sepehr Aghajanian (ORCID: https://orcid.org/0000-0001-6062-0138)
- Reza Samiee (ORCID: https://orcid.org/0009-0006-4862-1131)
- Fateme Mohammadifard
- Sheida Mobader Sani
- Romina Abyaneh
- Ali Kermanpour (ORCID: https://orcid.org/0000-0003-4362-0835)
Institutions
- Iran University of Medical Sciences (IR)
- UNSW Sydney (AU)
- Sina Hospital (IR)
- Jahrom University of Medical Sciences (IR)
- The George Institute for Global Health (AU)
- Iranian Orthopedic Association (IR)
- Alborz University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.38666
- Citations
- 11
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.24