Altered sterol composition mediates multiple tolerance of Kluyveromyces marxianus for xylitol production
This study elucidates the mechanism by which K. marxianus acquires resistance to various antifungal drugs, high temperatures, high osmolarity, acidity, and other stressors, through alterations in the composition and ratio of membrane sterols. By employing sterol engineering, the fermentation temperature of this unconventional thermotolerant K. marxianus was further elevated, ultimately providing an efficient platform for synthesizing high-value-added xylitol from biomass via the SSF process at temperatures exceeding 45 °C.
Authors
- Yujie Xie
- Lili Ren (ORCID: https://orcid.org/0000-0002-5140-1053)
- Xiurong Tao
- Qi Zhang (ORCID: https://orcid.org/0000-0002-6271-9163)
- Biao Zhang (ORCID: https://orcid.org/0000-0002-9627-7789)
- Feng Li (ORCID: https://orcid.org/0000-0003-1291-5315)
- Dayong Xu (ORCID: https://orcid.org/0000-0003-4967-1596)
- Hao Zha (ORCID: https://orcid.org/0000-0001-5982-7414)
- Jiacheng Li (ORCID: https://orcid.org/0000-0002-6708-6668)
- Zhongmei Hu
Institutions
- Huaibei Normal University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s12934-024-02546-3
- Citations
- 6
- Primary Topic
- Biofuel production and bioconversion
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Natural Science Foundation of China
- Huaibei Normal University