Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity
We identified a substantial number of adjacent CpG loci in human genome that display remarkably stable and cell type specific methylation pattern. The methylation pattern at these loci appears to reflect different methylation of alleles in cells. Furthermore, we showed that changes of methylation status at those loci are likely to be involved in regulation of the activity of enhancers and contribute to neoplastic transformation.
Authors
- Katarzyna Ewa Sokolowska (ORCID: https://orcid.org/0000-0002-9250-5799)
- Tomasz Kazimierz Wojdacz (ORCID: https://orcid.org/0000-0001-6003-2432)
- Olga Taryma‐Leśniak (ORCID: https://orcid.org/0000-0002-1161-5399)
- Konrad Borowski (ORCID: https://orcid.org/0000-0002-7835-3960)
- Jan Bińkowski
- Patrycja Kamila Przybylowicz (ORCID: https://orcid.org/0009-0004-0009-4710)
Institutions
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s13072-024-00555-5
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Narodowe Centrum Nauki
- Narodowa Agencja Wymiany Akademickiej