Tumor-derived IL-6 promotes chordoma invasion by stimulating tumor-associated macrophages M2 polarization and TNFα secretion
This study illustrates the dynamics between chordoma cells and TAMs in promoting chordoma invasion and suggests that IL-6/STAT3 pathway is a potential therapeutic target to reduce TAM-induced chordoma invasion.
Authors
- Jingjing Yang (ORCID: https://orcid.org/0000-0001-8521-7492)
- Weihai Ning
- Yanming Qu
- Mingshan Zhang
- Shengdian Wang (ORCID: https://orcid.org/0000-0002-9626-7900)
- Yuduo Guo (ORCID: https://orcid.org/0000-0002-7895-7430)
- Shenglun Li
- Chao Zhao (ORCID: https://orcid.org/0000-0001-7205-7629)
- Jiacheng Xu (ORCID: https://orcid.org/0000-0002-9292-6999)
- Yujia Chen (ORCID: https://orcid.org/0000-0002-9256-6188)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-6315-9997)
- Jun Wang (ORCID: https://orcid.org/0000-0002-7437-8503)
Institutions
- Capital Medical University (CN)
- Beijing Sanbo Brain Hospital (CN)
- Institute of Biophysics (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1016/j.intimp.2024.113315
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Key Technologies Research and Development Program