Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy
Decreased aberrant knee mechanical loading in patients with OA is associated with decreased biological and imaging measures of inflammation (measured in synovial fluid and on MRI) and increased anabolic processes. These exploratory findings suggest that improvement in knee loading can produce long-term (one year) improvement in joint physiology.
Authors
- C. Thomas Appleton (ORCID: https://orcid.org/0000-0001-7148-0767)
- Jenna M Schulz (ORCID: https://orcid.org/0000-0002-9279-4076)
- Hayden F. Atkinson (ORCID: https://orcid.org/0000-0002-1346-8177)
- Trevor B. Birmingham (ORCID: https://orcid.org/0000-0002-3300-7677)
- Holly T. Philpott (ORCID: https://orcid.org/0000-0002-6146-0241)
- Frank Beier (ORCID: https://orcid.org/0000-0002-8505-7537)
- J. Robert Giffin (ORCID: https://orcid.org/0000-0002-8227-0009)
Institutions
- Western University (CA)
- London Health Sciences Centre (CA)
- Fowler Kennedy Sport Medicine Clinic (CA)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s13075-024-03409-3
- Citations
- 2
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Canada Research Chairs
- Canadian Institutes of Health Research