Methotrexate promotes the release of granulocyte–macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling
MTX treatment induces secretion of IL-1 from activated RA-FLS which by autocrine signaling augments their release of GM-CSF. This unexpected effect of MTX might contribute to the persistence of synovitis.
Authors
- Tilia Selldén (ORCID: https://orcid.org/0009-0006-7969-4157)
- Miriam Bollmann (ORCID: https://orcid.org/0000-0003-1639-8079)
- Anna‐Karin Hultgård Ekwall (ORCID: https://orcid.org/0000-0001-8236-6089)
- Beatrice Bergström (ORCID: https://orcid.org/0000-0001-9065-0792)
- Mattias N. D. Svensson (ORCID: https://orcid.org/0000-0001-8077-9824)
Institutions
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s13075-024-03406-6
- Citations
- 7
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.29
Funders
- Göteborgs Universitet