miR-210 is essential to retinal homeostasis in fruit flies and mice
We provide the first morphological characterization of the retina of miR-210 KO and OE mice, investigating the role of this microRNA in mammalian retinal physiology and exploring potential parallels with phenotypes observed in fly models. Although the lack of similarities in lipid metabolism, circadian behaviour, and retinal transcriptome in mice suggests divergent mechanisms of retinal degeneration between the two species, transcriptome analysis of miR-210 KO fly brains indicates the potential existence of a shared upstream mechanism contributing to retinal degeneration in both flies and mammals.
Authors
- Annamaria Tisi (ORCID: https://orcid.org/0000-0002-8592-2412)
- Massimiliano Mazzone (ORCID: https://orcid.org/0000-0001-8824-4015)
- Germana Zaccagnini (ORCID: https://orcid.org/0000-0002-9441-4735)
- Mihai Bogdan Preda (ORCID: https://orcid.org/0000-0003-2500-4078)
- Daniela Taverna (ORCID: https://orcid.org/0000-0002-6365-527X)
- Cristiano De Pittà (ORCID: https://orcid.org/0000-0001-8013-8162)
- Paola Cusumano (ORCID: https://orcid.org/0000-0002-7627-3844)
- Rita Maccarone (ORCID: https://orcid.org/0000-0003-0648-3771)
- Cristiano Bertolucci (ORCID: https://orcid.org/0000-0003-0252-3107)
- Federico Virga (ORCID: https://orcid.org/0000-0003-2523-2070)
- Davide Colaianni (ORCID: https://orcid.org/0000-0002-1312-7540)
- Gabriele Sales (ORCID: https://orcid.org/0000-0003-2078-5661)
- Fabio Martelli (ORCID: https://orcid.org/0000-0002-8624-7738)
- Chiara Stefanelli
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- University of L'Aquila (IT)
- Spanish National Centre for Cardiovascular Research (ES)
- VIB-KU Leuven Center for Cancer Biology (BE)
- IRCCS Policlinico San Donato (IT)
- University of Turin (IT)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s13062-024-00542-6
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Università degli Studi di Padova