Der Kreis schließt sich: Nukleation von Mikrotubuli durch den γ-TuRC

Abstract Microtubules, essential components of the cytoskeleton, are assembled from α/β-tubulin subunits by the γ-tubulin ring complex (γ-TuRC). Over the last five years, cryo-electron microscopy studies have advanced our structural and mechanistic understanding of this process by elucidating structures of the γ-TuRC from different organisms and, very recently, after microtubule nucleation under varying conditions.