The role of lipid biosynthesis machinery in cellular membrane adaptation

Abstract Cells need to adapt their membranes to environmental changes. In this process the specific lipid composition of the membrane is of importance. The lipid biosynthesis machinery has direct influence on the membrane lipid content by 1) producing newly synthesized lipids, 2) remodeling already existing lipids, such as various cardiolipins. The interactions between components of the lipid biosynthesis machinery are crucial to obtain a specific lipid composition, but the interplay is largely unknown.