Chemotherapy combined with immune checkpoint inhibitors may overcome the detrimental effect of high neutrophil-to-lymphocyte ratio prior to treatment in esophageal cancer patients
High NLR in EC patients prior to treatment was significantly less effective for ICIs. In chemotherapy combined with ICIs, NLR before the treatment was not associated with treatment efficacy, suggesting combination chemotherapy may be beneficial for EC patients with high NLR. NLR may be an indicator of immunocompetence in anti-tumor immunity and a convenient predictive biomarker for selecting appropriate treatments including ICIs.
Authors
- Toshiaki Tsurui (ORCID: https://orcid.org/0000-0002-6167-8953)
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Kiyoshi Yoshimura (ORCID: https://orcid.org/0000-0003-4816-1826)
- Tomotake Ariyoshi
- Hirotsugu Ariizumi (ORCID: https://orcid.org/0000-0003-1663-8730)
- Masahiko Murakami (ORCID: https://orcid.org/0000-0001-6233-5015)
- Ryotaro Ohkuma (ORCID: https://orcid.org/0000-0003-4121-2491)
- Atsushi Horiike (ORCID: https://orcid.org/0000-0002-1632-3125)
- Satoru Goto (ORCID: https://orcid.org/0000-0001-8088-9070)
- Tomoyuki Ishiguro
- Masahiro Shimokawa (ORCID: https://orcid.org/0000-0002-8645-4112)
- Nana Iriguchi
- Koji Otsuka (ORCID: https://orcid.org/0000-0002-9625-785X)
- Yuya Hirasawa
- Satoshi Wada (ORCID: https://orcid.org/0000-0003-1276-6620)
- Takeshi Yamashita (ORCID: https://orcid.org/0000-0002-8489-5985)
- Emiko Mura
- Yuji Kiuchi
- Risako Suzuki
- Takuya Tsunoda
Institutions
- SHOWA Medical University (JP)
- SHOWA Medical University Hospital (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fonc.2024.1449941
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00