Wnt-Signaltransduktion in motilen Zilien und Geißeln

Abstract Motile cilia are essential for many biological processes, including mucus transport in the human airway or in the male and female reproductive system. Unraveling their biogenesis and mechanisms regulating their coordinate beating motion are of medical interest to understand ciliopathies. We recently discovered that cilia are Wnt signaling organelles. Here, we discuss the intraciliary Wnt/GSK3 signaling axis that is required for cilia biogenesis and for motile cilia function.