AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson’s disease
The pathological role in the hippocampus and the cell-to-cell transmissibility of AIMP2 provide new therapeutic avenues for PD treatment, and plasma AIMP2 combined with α-synuclein may improve the accuracy of PD diagnosis in the early stages.
Authors
- Nae‐Eung Lee (ORCID: https://orcid.org/0000-0002-6539-5010)
- Jeong‐Yong Shin (ORCID: https://orcid.org/0000-0002-9614-9955)
- Sangwoo Ham (ORCID: https://orcid.org/0000-0003-4569-2584)
- Sang Seong Kim (ORCID: https://orcid.org/0000-0002-9021-8307)
- Hee-Tae Kim (ORCID: https://orcid.org/0000-0002-7722-4841)
- Seok Hyun Cho (ORCID: https://orcid.org/0000-0001-8218-5894)
- Ji Hun Kim (ORCID: https://orcid.org/0000-0003-3183-9709)
- Heejeong Kim (ORCID: https://orcid.org/0000-0002-9801-5088)
- Yunjong Lee (ORCID: https://orcid.org/0000-0003-0182-2279)
- Gum Hwa Lee
Institutions
- Chosun University (KR)
- Samsung Medical Center (KR)
- Gwangju Institute of Science and Technology (KR)
- ToolGen (South Korea) (KR)
- Hanyang University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s12967-024-05666-x
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea