Regiodivergent Radical-Relay Alkene Dicarbofunctionalization
Herein, we report a regiodivergent 1,n-dicarbofunctionalization of unactivated olefins enabled by a Ni-catalyzed radical relay that forges both C(<i>sp</i><sup>3</sup>)-C(<i>sp</i><sup>3</sup>) and C(<i>sp</i><sup>2</sup>)-C(<i>sp</i><sup>3</sup>) linkages, even at long-range. Initial studies support an intertwined scenario resulting from the merger of an atom-transfer radical addition (ATRA) and a chain-walking event, with site-selectivity being dictated by a judicious choice of the ligand backbone.
Authors
- Rubén Martı́n (ORCID: https://orcid.org/0000-0002-2543-0221)
- Z.H. Liu (ORCID: https://orcid.org/0000-0002-9199-6493)
- Francesco D’Amico (ORCID: https://orcid.org/0000-0001-8984-5795)
Institutions
- University of Siena (IT)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Institut Català d'Investigació Química (ES)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1021/jacs.4c10204
- Citations
- 16
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Institut Català d'Investigació Química
- HORIZON EUROPE Marie Sklodowska-Curie Actions