Macro- and Microstructural White Matter Differences in Neurologic Postacute Sequelae of SARS-CoV-2 Infection
NeuroPASC participants reported symptoms of lower concentration, higher fatigue, and impaired cognition compatible with WM syndrome. Psychometric testing confirmed these findings. NeuroPASC participants exhibited larger cerebral WM volume and higher WM mean kurtosis than NoCOVID controls. These findings suggest that immune dysregulation could influence WM properties to produce WM volume increases and consequent cognitive effects and headaches. Further work will be needed to establish mechanistic links among these variables.
Authors
- Rory O’Brien (ORCID: https://orcid.org/0000-0002-0674-4815)
- Nikita Rednam
- Peter Rock (ORCID: https://orcid.org/0000-0003-2250-5926)
- Thomas A. Zeffiro (ORCID: https://orcid.org/0000-0002-0846-4577)
- Andrea R. Levine (ORCID: https://orcid.org/0000-0003-4103-1025)
- Erin E. O’Connor (ORCID: https://orcid.org/0000-0002-9483-1117)
- Rosângela Salerno-Gonçalves (ORCID: https://orcid.org/0000-0003-2999-4275)
Institutions
- University of Maryland, Baltimore (US)
- Westminster College - Missouri (US)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.3174/ajnr.a8481
- Citations
- 4
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Georgia Clinical and Translational Science Alliance
- National Institute of Mental Health
- National Center for Advancing Translational Sciences