Clinical and Genomic Characterization of <i>ERBB2</i> -Altered Gallbladder Cancer: Exploring Differences Between an American and a Chilean Cohort
The prevalence of lithiasis seems to be higher in Chilean versus US patients with GBC. A similar prevalence of <i>ERBB2</i> alterations of overall 14% and better OS suggests that a proportion of them could benefit from human epidermal growth factor receptor type 2-targeted therapies. The smaller cohort of Chile, where the disease prevalence is higher, is a reminder and invitation for the need of more robust next-generation sequencing analyses globally.
Authors
- Henry S. Walch (ORCID: https://orcid.org/0000-0003-1188-350X)
- Walid K. Chatila (ORCID: https://orcid.org/0000-0001-5474-218X)
- Bruno Nervi (ORCID: https://orcid.org/0000-0002-3016-7261)
- Nikolaus Schultz (ORCID: https://orcid.org/0000-0002-0131-4904)
- Patricia Macanas (ORCID: https://orcid.org/0000-0003-2631-8618)
- Bob T. Li (ORCID: https://orcid.org/0000-0001-6661-8733)
- Juan Carlos Roa (ORCID: https://orcid.org/0000-0001-8313-8774)
- Santiago A. Sepúlveda (ORCID: https://orcid.org/0000-0002-0907-903X)
- James J. Harding (ORCID: https://orcid.org/0000-0002-7029-4310)
- Amin Yaqubie (ORCID: https://orcid.org/0009-0001-0158-6774)
- Sebastián Mondaca (ORCID: https://orcid.org/0000-0002-1130-0370)
- Gonzalo Muñoz (ORCID: https://orcid.org/0000-0002-4597-2458)
- Paola Viviani (ORCID: https://orcid.org/0000-0003-2886-5228)
- Claudia Pareja-Barrueto (ORCID: https://orcid.org/0000-0002-2320-1564)
- Ghassan K. Abou‐Alfa (ORCID: https://orcid.org/0000-0002-1522-8054)
- Patricia Garcia (ORCID: https://orcid.org/0000-0002-7922-8432)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Pontificia Universidad Católica de Chile (CL)
- Trinity College Dublin (IE)
- Cornell University (US)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- JCO Global Oncology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1200/go.24.00090
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Conquer Cancer Foundation
- Memorial Sloan-Kettering Cancer Center
- Cycle for Survival
- European Commission
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias