Insight of autonomic dysfunction in CLN3 disease: a study on episodes resembling paroxysmal sympathetic hyperactivity (PSH)
The documented transient withdrawal of parasympathetic activity leading to a paroxysmal unbalanced sympathetic hyperactivity most probably accounts for the PSH-like episodes occurring in post-adolescent CLN3 patients. The findings shed new light on both aetiology and possible preventative and therapeutic measures.
Authors
- John R. Østergaard (ORCID: https://orcid.org/0000-0002-3906-0831)
- Mette Møller Handrup (ORCID: https://orcid.org/0000-0001-5341-239X)
- Cecilie Ejerskov (ORCID: https://orcid.org/0000-0003-3815-0613)
- Henrik Kjærulf Jensen (ORCID: https://orcid.org/0000-0003-1802-4302)
- C Baekmann
- H Molgaard
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s13023-024-03336-1
- Citations
- 6
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- H. Lundbeck A/S