Comprehensive population pharmacokinetic modelling of sugemalimab, an anti‐programmed death‐ligand 1 (PD‐L1) human monoclonal antibody, in patients with solid tumours or lymphomas across multiple Phase I–III studies
The PopPK model adequately described the pharmacokinetic profile of sugemalimab with no clinically meaningful impact observed on its exposure across all covariates. Dose adjustment does not appear to be necessary.
Authors
- Yucheng Sheng (ORCID: https://orcid.org/0000-0003-1460-5070)
- Kun Wang (ORCID: https://orcid.org/0000-0003-2609-6058)
- Fengyan Xu (ORCID: https://orcid.org/0009-0005-9037-1765)
- Z. Pan (ORCID: https://orcid.org/0009-0002-5797-4132)
- Archie Tse
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1111/bcp.16276
- Citations
- 4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.68