Infections Combined With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Case Report and Systematic Review of the Literature

Myelinating oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system. Its specific etiology and pathogenesis remain unclear. In recent years, there have been increasing reports of MOGAD occurring after infections. Even cases of concurrent infection and MOGAD have been documented. We report a clinical case of a 14-year-old male patient admitted to the hospital with a fever and loss of consciousness. He underwent thorough medical examinations. The results of second-generation sequencing of the metagenome of the cerebrospinal fluid revealed that he was infected with Haemophilus parainfluenzae, and serum testing showed positive MOG antibodies. He was discharged after improving with intravenous immunoglobulin and other treatments.