Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity
In conclusion, our data revealed that SFKs antagonism reduced photophobia processing in male mice and exhibited gender-different modulation of trigeminal ganglion activity, primarily manifesting as alterations in the transcriptome profile. These findings underscore the potential of SFKs antagonism for allieving photophobia in males, highlighting its value in the emerging field of precision medicine.
Authors
- Minyan Wang (ORCID: https://orcid.org/0000-0002-7955-1627)
- Sulev Kõks (ORCID: https://orcid.org/0000-0001-6087-6643)
- John P. Quinn (ORCID: https://orcid.org/0000-0003-3551-7803)
- Lingdi Nie (ORCID: https://orcid.org/0000-0002-9707-5898)
- Aditi Kanhere
- Junyu Yao
- Zhuoan Huang
- Xuechunhui Xiong
- Xinchen Nie
Institutions
- University of Liverpool (GB)
- Murdoch University (AU)
- Perron Institute for Neurological and Translational Science (AU)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s10194-024-01875-3
- Citations
- 4
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Xi’an Jiaotong-Liverpool University