Chest Wall Deformities in Adults With Fibrotic Interstitial Lung Disease Related to Surfactant-Related Gene Mutations
To the Editor:Chest wall deformity (CWD) is a structural abnormality reported in 0.4% of the general adult population. 1 It can be acquired or congenital.Acquired CWD can occur due to chest surgery, radiotherapy, or hernia surgery, 2 unlike congenital CWD that is diagnosed at birth. 3 The most common types of CWD are pectus excavatum (88%, breastbone pushes inward), pectus carinatum (9%, breastbone and ribs protrude), and thoracic asymmetry. 3Scoliosis is overrepresented in patients with CWD (20%) compared with the general population (2%-4%). 4ost CWDs that appear before 3 years of age regress spontaneously; those occurring after 10 years of age deteriorate in one-third of cases. 5The potential association between chronic lung disease and increased incidence of CWD has been suggested with bronchopulmonary dysplasia and pectus excavatum < 1 year, or cystic fibrosis and pectus carinatum in childhood. 6,7However, the increased incidence of CWD in the context of fibrotic interstitial lung disease (FILD) has not been studied in adults. 8
Authors
- Margot Delin (ORCID: https://orcid.org/0009-0008-2262-2501)
- Nadia Nathan (ORCID: https://orcid.org/0000-0001-5149-7975)
- Marie Legendre (ORCID: https://orcid.org/0000-0003-2178-0846)
- Justine Frija‐Masson (ORCID: https://orcid.org/0000-0001-5575-3913)
- L Wemeau (ORCID: https://orcid.org/0000-0003-4962-6680)
- Effrosyni D. Manali (ORCID: https://orcid.org/0000-0002-1731-7069)
- Bruno Crestani (ORCID: https://orcid.org/0000-0002-2961-3455)
- Laurent Plantier (ORCID: https://orcid.org/0000-0002-3426-2936)
- Raphaël Borie (ORCID: https://orcid.org/0000-0002-9906-0024)
- Marie‐Pierre Debray (ORCID: https://orcid.org/0000-0003-2109-5662)
- Emmanuel Brian
- Spyros A. Papiris
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Université de Tours (FR)
- Inserm (FR)
- National and Kapodistrian University of Athens (GR)
- Université Côte d'Azur (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Institute Mutualiste Montsouris (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- NeuroDiderot (FR)
- Maladies génétiques d’expression pédiatrique
Publication Details
- Journal
- CHEST Pulmonary
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1016/j.chpulm.2024.100106
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Sanofi
- Fondation du Souffle