Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling
Quercetin's action on multiple target molecules and pathways makes it a promising treatment for cartilage injury in rheumatoid arthritis. By reducing joint inflammation, improving joint metabolic homeostasis, and decreasing immune system activation energy, quercetin inhibits the JAK1/STAT3/HIF-1α signaling pathway to improve disease status.
Authors
- Guifeng Hao
- FengQi Zhang
- ZhiJun Xie
- Zhiyu Li (ORCID: https://orcid.org/0000-0001-6492-9511)
- Ying Cai (ORCID: https://orcid.org/0000-0002-1782-719X)
- Yiyang Zhang (ORCID: https://orcid.org/0000-0001-6748-8272)
- JiaWang Zhou
- Jing Sun (ORCID: https://orcid.org/0000-0001-7104-8026)
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s10020-024-00929-1
- Citations
- 35
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 9.89
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Zhejiang Traditional Chinese Medicine Administration
- Natural Science Foundation of Zhejiang Province