Liquid chromatography-mass spectrometric method for the simultaneous analysis of branched-chain amino acids and their ketoacids from dried blood spot as secondary analytes for the detection of maple syrup urine disease
The developed DBS method, requiring no derivatization and involving simple sample preparation with short run times, is a cost-effective and reliable approach for the confirmatory diagnosis of MSUD.
Authors
- Leslie Lewis (ORCID: https://orcid.org/0000-0002-3467-6821)
- Arya Raveendran (ORCID: https://orcid.org/0000-0002-1675-0995)
- Krishnananda Prabhu (ORCID: https://orcid.org/0000-0003-3479-9597)
- Sudheer Moorkoth (ORCID: https://orcid.org/0000-0002-5341-0981)
- Ashutosh Gupta (ORCID: https://orcid.org/0000-0003-4236-6580)
Institutions
- Manipal Academy of Higher Education (IN)
- Kasturba Medical College, Manipal (IN)
Publication Details
- Journal
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1016/j.jmsacl.2024.10.001
- Citations
- 5
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.91
Funders
- Manipal Academy of Higher Education
- Government of Canada
- Grand Challenges Canada