Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits
CDC25A significantly increased the cholesterol metabolism through endosome pathway in quiescent cancer cells, leading to the significant changes in cytoskeleton and membrane properties so as to enhance the resistance of mechanical force in circulatory system, facilitating lung metastasis. In high-density cultivation, quiescent cancer cells, up-regulate cholesterol metabolism by CDC25A through endosome pathway, enhancing the resistance to mechanical force in circulatory system, facilitating lung metastasis.
Authors
- Xingyang Liu (ORCID: https://orcid.org/0000-0001-9119-8478)
- Xinxin Cheng (ORCID: https://orcid.org/0000-0001-6485-8960)
- Di Yang
- Lei Xiao (ORCID: https://orcid.org/0000-0002-0428-1749)
- Mengzhu Lv (ORCID: https://orcid.org/0000-0002-7804-2636)
- Weimin Zhang (ORCID: https://orcid.org/0000-0002-6260-3443)
- Siqi Liu (ORCID: https://orcid.org/0009-0006-4715-0593)
- Qimin Zhan (ORCID: https://orcid.org/0000-0002-1731-938X)
- Chen Xu (ORCID: https://orcid.org/0000-0001-8068-2109)
- Huihui Zhao (ORCID: https://orcid.org/0000-0002-7607-3527)
- Qinjie Min
- Yidi Tai
- Qingnan Wu (ORCID: https://orcid.org/0000-0002-1469-941X)
- Yan Wang (ORCID: https://orcid.org/0000-0001-6111-5379)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Soochow University (CN)
- National Cancer Center (US)
- Peking University Cancer Hospital (CN)
- Peking University International Hospital (CN)
- Ministry of Education (ET)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1038/s41416-024-02861-x
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking University
- National Key Research and Development Program of China