Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
• Cochlear implant/MXene-based electricacoustic stimulation system is proposed and constructed. • Low-frequency electroacoustic stimulation promotes the growth and development of SGNs. • Low-frequency electroacoustic stimulation promotes higher frequency calcium oscillations in the SGNs. • The SGN growth under full-band electroacoustic stimulation is investigated. Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.
Authors
- Xia Gao (ORCID: https://orcid.org/0000-0002-4539-5929)
- Hao Wei
- Jieyu Qi (ORCID: https://orcid.org/0000-0001-8780-0710)
- Dongyu Xu (ORCID: https://orcid.org/0000-0001-5217-5417)
- Yangnan Hu (ORCID: https://orcid.org/0000-0003-4700-6701)
- Shan Zhou (ORCID: https://orcid.org/0000-0002-6476-3280)
- Renjie Chai (ORCID: https://orcid.org/0000-0002-3885-543X)
- Shanying Han (ORCID: https://orcid.org/0000-0001-8403-1020)
- Menghui Liao
- Qingyue Cui
- Cheng Hong (ORCID: https://orcid.org/0009-0002-4372-5637)
- Bin Zhang (ORCID: https://orcid.org/0000-0003-2522-6789)
- Yusong Wang (ORCID: https://orcid.org/0000-0002-5424-8824)
- Lei Tian (ORCID: https://orcid.org/0000-0002-5609-0098)
- Wenyan Li (ORCID: https://orcid.org/0000-0001-9575-7812)
- Ye Yang (ORCID: https://orcid.org/0000-0003-2314-4579)
- Xin Gao
- Xugang Zhuang
Institutions
- University of Electronic Science and Technology of China (CN)
- Shandong University (CN)
- Nantong University (CN)
- Zhongda Hospital Southeast University (CN)
- Nanjing Drum Tower Hospital (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shandong Provincial Hospital (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Engineered Regeneration
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.engreg.2024.10.001
- Citations
- 2
- Primary Topic
- MXene and MAX Phase Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.23