Integrated metabolomics and network pharmacology to reveal the mechanisms of Shexiang Baoxin pill against atherosclerosis
Taken together, based on the integrated metabolomics and network pharmacology, our findings suggest that SBP may be implicated in TMAO-induced atherosclerosis by affecting endothelial function and bile acid synthesis. We observed that SBP may ameliorate atherosclerosis by regulating TMAO levels through multiple pathways, which may provide a novel direction and insight for SBP involved in cardiovascular protection by mediating the gut-heart axis.
Authors
- Daisong Li (ORCID: https://orcid.org/0000-0002-3886-0853)
- Yuanyuan Hou
- Banghui Wang
- Ruolan Chen
- Guoliang Zhang (ORCID: https://orcid.org/0000-0002-7371-3349)
- Bing Li (ORCID: https://orcid.org/0000-0001-6504-2728)
- Xiaojian Xu (ORCID: https://orcid.org/0000-0002-5264-8963)
- Xian‐Ming Chu (ORCID: https://orcid.org/0000-0003-4755-162X)
- Zhaoqing Li (ORCID: https://orcid.org/0009-0002-5504-7802)
- Chao Huang (ORCID: https://orcid.org/0000-0002-0674-1323)
Institutions
- Qingdao University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Affiliated Hospital of Qingdao University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1016/j.phymed.2024.156138
- Citations
- 20
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province