Mechanism of KMT2D-mediated epigenetic modification in IL-1β-induced nucleus pulposus cell degeneration.
KMT2D promoted miR-133a-5p expression through H3K4me2 methylation, thereby promoting the binding of miR-133a-5p to PFKFB2, reducing the mRNA level of PFKFB2, promoting inflammation and apoptosis of IL-1β-induced NPCs, and inhibiting NPC proliferation.
Authors
- Hongjiang Liu (ORCID: https://orcid.org/0000-0001-9322-7121)
- Hai‐Quan Liu (ORCID: https://orcid.org/0000-0002-4065-336X)
- Zuyu Meng
- Wensheng Zhang (ORCID: https://orcid.org/0000-0002-4712-8656)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
- Huizhou Central People's Hospital (CN)
- Guangzhou Medical University (CN)
- Huizhou University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-01
- DOI
- https://doi.org/10.14670/hh-18-813
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00