Development and Characterization of A Novel SpyTagged Modular Nanobody as A Detection Platform for CD22-Positive Cells.
The novel FITC-SpyC-SpyT-CD22Nb produced in the present study is capable of detecting the surficial expression of CD22. According to our findings, FITC-SpyC-SpyT-CD22Nb is applicable for specific targeting of CD22 in a therapeutic manner, i.e., chimeric antigen receptor (CAR)-T cell therapy and antibody drug conjugates (ADCs).
Authors
- Arash Arashkia (ORCID: https://orcid.org/0000-0002-3117-3217)
- Mahdi Habibi‐Anbouhi (ORCID: https://orcid.org/0000-0002-3151-152X)
- Amirhosein Maali (ORCID: https://orcid.org/0000-0002-0699-3010)
- Ahmad Noei
- Zahra Sharifzadeh (ORCID: https://orcid.org/0000-0002-4419-0315)
- Maryam Kadkhodazadeh
- Mahdieh Motamedi‐Rad
- Shahriyar Abdoli (ORCID: https://orcid.org/0000-0002-4052-332X)
Institutions
- Pasteur Institute of Iran (IR)
- Golestan University (IR)
- Golestan University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-07
- DOI
- https://doi.org/10.22074/cellj.2024.2028911.1573
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00