Network-based pharmacology and experimental validation to explore the mechanism of action of the Jiawei Pentongling formula for the treatment of endometriosis-related pain.
The present study preliminarily analyzed the pharmacological mechanism of the formula, and molecular docking and animal experiments showed the feasibility of this study, suggesting that the formula may inhibit the release of inflammatory factors and reverse the pain associated with EMs by downregulating the PI3K/Akt signaling pathway.
Authors
- Xiaoqing Liu (ORCID: https://orcid.org/0000-0003-0982-4615)
- Xia Yu (ORCID: https://orcid.org/0000-0002-3253-2883)
- Shiwen Zhang (ORCID: https://orcid.org/0000-0002-9341-3765)
- Ya-Jie Liu (ORCID: https://orcid.org/0000-0002-2249-4318)
- FU Jin-rong
- Y U Siyun
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20240806.004
- Citations
- 1
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47