Regulatory effects of the p38 mitogen-activated protein kinase-myosin light chain kinase pathway on the intestinal epithelial mechanical barrier and the mechanism of modified Pulsatilla decoction in the treatment of ulcerative colitis.
The p38MAPK-MLCK signaling pathway can affect mechanical barrier function and TJ expression in the intestinal epithelium. MPD restores TJ expression and attenuates intestinal epithelial barrier damage by suppressing the p38MAPK-MLCK pathway.
Authors
- Yang Xin (ORCID: https://orcid.org/0000-0002-8315-8000)
- Liang Guoqiang
- Jinwei Guo (ORCID: https://orcid.org/0000-0002-6741-721X)
- Peipei Zhang (ORCID: https://orcid.org/0000-0003-1742-1680)
- Hui Zhu (ORCID: https://orcid.org/0000-0001-8609-4754)
- Meng Wang (ORCID: https://orcid.org/0000-0002-2469-3222)
- Hongwen Sun (ORCID: https://orcid.org/0009-0007-1260-4070)
- Huiping Zhu (ORCID: https://orcid.org/0000-0001-8813-2814)
- Wang Ting-ting
Institutions
- Suzhou University of Science and Technology (CN)
- Suzhou Municipal Hospital (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20240806.006
- Citations
- 5
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province