Neuroprotective agents ineffective in mitigating autonomic dysreflexia following experimental spinal cord injury
Despite promising beneficial effect reported in previous studies, none of the drugs demonstrated improvement in cardiovascular or motor function. Indomethacin and Valproic acid exhibited unexpected high mortality at doses deemed safe in the literature. This emphasizes the necessity for reproducibility studies in pre-clinical research and underscores the importance of publishing null findings to guide future investigations.
Authors
- Kiran Pawar
- Steven Cao
- Rahul Sachdeva (ORCID: https://orcid.org/0000-0001-7972-9344)
- Andrei V. Krassioukov (ORCID: https://orcid.org/0000-0002-0022-7972)
- Jordan W. Squair (ORCID: https://orcid.org/0000-0003-0551-859X)
- Tamila Kalimullina
- Wolfram Tetzlaff (ORCID: https://orcid.org/0000-0003-3462-1676)
- Arshdeep Marwaha (ORCID: https://orcid.org/0000-0001-5405-204X)
- Christopher Roy West (ORCID: https://orcid.org/0000-0002-0815-4122)
- Jie Liu (ORCID: https://orcid.org/0000-0002-7638-187X)
- Ward T. Plunet
Institutions
- University of British Columbia (CA)
- International Collaboration On Repair Discoveries (CA)
- University of Lausanne (CH)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1016/j.expneurol.2024.114993
- Citations
- 1
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- U.S. Department of Defense
- Wings for Life
- WorkSafeBC
- Coloplast
- Canadian Institutes of Health Research