Loss of mitochondrial Ca2+ response and CaMKII/ERK activation by LRRK2R1441G mutation correlate with impaired depolarization-induced mitophagy
Pathogenic LRRK2<sup>R1441G</sup> mutation abolished mitochondrial depolarization-induced Ca<sup>2+</sup> response and impaired the basal mitochondrial clearance. Inherent defects from LRRK2 mutation have weakened the cellular ability to scavenge damaged mitochondria, which may further aggravate mitochondrial dysfunction and neurodegeneration in PD.
Authors
- D. Ramsden (ORCID: https://orcid.org/0000-0002-0927-1304)
- Eunice Eun-Seo Chang
- Michelle Hiu-Wai Kung (ORCID: https://orcid.org/0000-0001-8979-1352)
- Zoe Yuen-Kiu Choi
- Yasine Malki (ORCID: https://orcid.org/0009-0004-3381-2344)
- Philip Wing‐Lok Ho (ORCID: https://orcid.org/0000-0001-7794-0146)
- Huifang Liu (ORCID: https://orcid.org/0000-0002-0214-0045)
- Shu-Leong Ho
- Shirley Yin-Yu Pang
- Steffi Xi-Yue Zhang
Institutions
- Hong Kong Polytechnic University (HK)
- City University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- University of Birmingham (GB)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s12964-024-01844-y
- Citations
- 9
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Hong Kong Polytechnic University