Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
The compendium of programs presented here provides a basis for rational targeting of tumor and/or TME components. We anticipate that our approach will facilitate an ecosystem-level understanding of the immediate and long-term consequences of such perturbations, including the identification of compensatory programs that will inform improved combinatorial therapies.
Authors
- Douglas J. Mahoney (ORCID: https://orcid.org/0000-0002-0642-992X)
- Aly Abdelkareem (ORCID: https://orcid.org/0000-0002-2203-9577)
- Donna L. Senger (ORCID: https://orcid.org/0000-0003-2403-3395)
- Xueqing Lun (ORCID: https://orcid.org/0000-0001-9728-2996)
- Courtney Hall (ORCID: https://orcid.org/0000-0002-6115-1027)
- A. Sorana Morrissy (ORCID: https://orcid.org/0000-0001-8526-562X)
- Kata Osz
- Varsha Thoppey Manoharan (ORCID: https://orcid.org/0009-0009-6547-2221)
- Laura Mah
- Heewon Seo (ORCID: https://orcid.org/0000-0002-2639-0065)
- Aaron H. Gillmor
- Jennifer A. Chan (ORCID: https://orcid.org/0000-0001-9798-1551)
- Franz J. Zemp (ORCID: https://orcid.org/0000-0002-8845-3535)
- Ngoc Ha Dang
- Samuel Morris Brown (ORCID: https://orcid.org/0000-0003-1206-6261)
- Kiran Narta (ORCID: https://orcid.org/0000-0002-0645-6581)
- Sean Grewal
- Bo Young Ahn
Institutions
- University of Calgary (CA)
- Jewish General Hospital (CA)
- Alberta Children's Hospital (CA)
- Alberta Bone and Joint Health Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Genome biology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s13059-024-03407-3
- Citations
- 13
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.04