Identification and experimental validation of a sialylation–related long noncoding RNA signature for prognosis of bladder cancer

In this study, we examined the relationship between sialylation-related lncRNA and the prognosis of bladder cancer, providing new molecular markers and potential targets for diagnosis and treatment. Our research revealed correlations between sialylation-related lncRNA characteristics and clinicopathological features, potential mechanisms, somatic mutations, immune microenvironment, chemotherapy response, and predicted drug sensitivity in bladder cancer. Additionally, in vitro cellular studies were conducted to validate these findings and lay the groundwork for future clinical applications.

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Publication Details

Journal
BMC Urology
Published
2024-10-10
DOI
https://doi.org/10.1186/s12894-024-01613-6
Citations
2
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
0.57

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article

Identification and experimental validation of a sialylation–related long noncoding RNA signature for prognosis of bladder cancer

Haitao Niu, Xintao Tian, Shengxian Li, Yi Qiao
2 citations
BMC Urology
Cancer-related molecular mechanisms research
0.57
article

Identification and experimental validation of a sialylation–related long noncoding RNA signature for prognosis of bladder cancer

Haitao Niu, Xintao Tian, Shengxian Li, Yi Qiao
article en
2 citations

Abstract

In this study, we examined the relationship between sialylation-related lncRNA and the prognosis of bladder cancer, providing new molecular markers and potential targets for diagnosis and treatment. Our research revealed correlations between sialylation-related lncRNA characteristics and clinicopathological features, potential mechanisms, somatic mutations, immune microenvironment, chemotherapy response, and predicted drug sensitivity in bladder cancer. Additionally, in vitro cellular studies were conducted to validate these findings and lay the groundwork for future clinical applications.

BMC UrologyVol. 24(1)
Qingdao University (CN), Affiliated Hospital of Qingdao University (CN)
National Natural Science Foundation of China, Qingdao University
Openalex Percentile: Top 31%
Cancer-related molecular mechanisms research
0.57
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