Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion
Glioblastomas with SVZ infiltration exhibit distinct imaging characteristics, including higher perfusion and lower cell density per voxel, indicating a more infiltrative growth and higher vascularization. Stem cell-like characteristics in SVZ-infiltrating cells could explain the increased infiltration and aggressive behavior. Understanding these imaging and biological correlations could enhance the understanding of glioblastoma evolution.
Authors
- Julian Ziegenfeuter (ORCID: https://orcid.org/0000-0001-7306-7554)
- Meike Mitsdoerffer (ORCID: https://orcid.org/0000-0002-5260-9956)
- Marie‐Christin Metz (ORCID: https://orcid.org/0000-0002-1459-5741)
- Claire Delbridge (ORCID: https://orcid.org/0000-0003-4339-6917)
- Bernhard Meyer (ORCID: https://orcid.org/0000-0001-6486-7955)
- Benedikt Wiestler (ORCID: https://orcid.org/0000-0002-2963-7772)
- Severin Schramm (ORCID: https://orcid.org/0000-0002-3299-5861)
- Kirsten Jung (ORCID: https://orcid.org/0000-0003-0779-6841)
- Friederike Schmidt‐Graf (ORCID: https://orcid.org/0000-0002-3515-4427)
- Michael Griessmair (ORCID: https://orcid.org/0009-0007-3518-0792)
- Claus Zimmer (ORCID: https://orcid.org/0000-0002-4805-9103)
- Julian Canisius (ORCID: https://orcid.org/0009-0002-4490-8021)
Institutions
- TUM Klinikum (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1007/s11060-024-04849-2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Technische Universität München