KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer
Our data revealed a previously unidentified function of KLF14 in promoting ferroptosis, which results in the suppression of cell proliferation. Mechanistically, we revealed a novel regulatory mechanism by which KLF14 targets GPX4. These findings suggest a novel strategy to induce ferroptosis through the targeting of KLF14 in human cervical cancer cells.
Authors
- Xuchao Ding
- Lili Cao (ORCID: https://orcid.org/0000-0003-4608-0723)
- Rui Guo (ORCID: https://orcid.org/0000-0002-7674-073X)
- Hui Ye (ORCID: https://orcid.org/0000-0002-8473-0603)
- Ruonan Li (ORCID: https://orcid.org/0000-0002-9581-2620)
- Jin Qiu (ORCID: https://orcid.org/0009-0007-5464-1806)
- Ying Du
- XinRan Lv
Institutions
- Shandong University (CN)
- Linyi People's Hospital (CN)
- Shandong Tumor Hospital (CN)
- Shanghai Public Health Clinical Center (CN)
- Binzhou People's Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-10
- DOI
- https://doi.org/10.1186/s12967-024-05714-6
- Citations
- 16
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Natural Science Foundation of Shandong Province