Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway
In summary, our study is the first to demonstrate that HG regulates the phosphorylation of FOXO1, affecting the proliferation, migration, and invasion of HCC cells. The findings suggest that HG can inhibit the migration of HCC cells in vitro. The data indicate that HG-mediated targeting of the FOXO1/FOXO6 pathway holds promise as a novel therapeutic approach.
Authors
- Songzhe Li (ORCID: https://orcid.org/0009-0000-8519-8113)
- Yang Sun (ORCID: https://orcid.org/0000-0003-4312-6327)
- Shuchang Bao
Institutions
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1371/journal.pone.0310930
- Citations
- 4
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China