The PTK2B gene is associated with obesity, adiposity, and leptin levels in children and adolescents
Previous studies determined that Pyk2 is involved in several diseases in which the symptomatology presents alterations in energy balance. However, its role in obesity is poorly understood. To evaluate the metabolic role of the Pyk2 gene (<i>PTK2B</i>) in children and adolescents with obesity we measured its mRNA expression levels in peripheral blood mononuclear cells. For that we performed a cross-sectional study involving 130 Caucasian subjects that was divided into two groups according to BMI. Data showed increased <i>PTK2B</i> mRNA expression in children and adolescents with obesity. Interestingly, a positive correlation has been found between the levels of <i>PTK2B</i> with weight, BMI, BMI <i>Z</i> score, fat mass, waist circumference, waist to height ratio, diastolic blood pressure, and leptin. In addition, it is indicated that high levels of <i>PTK2B</i> gene expression might be a predictor of obesity development. This work provides important insights into the previously undescribed role of Pyk2 in obesity.
Authors
- Omar Al–Massadi (ORCID: https://orcid.org/0000-0003-0645-6159)
- Beatriz Brea‐García (ORCID: https://orcid.org/0000-0001-5691-9364)
- Raquel Pérez-Lois (ORCID: https://orcid.org/0000-0001-7352-3580)
- Javier Conde (ORCID: https://orcid.org/0000-0002-2187-479X)
- Luísa M. Seoane (ORCID: https://orcid.org/0000-0003-1004-9898)
- Ana Estany‐Gestal (ORCID: https://orcid.org/0000-0001-7997-3603)
- Rocío Vázquez‐Cobela (ORCID: https://orcid.org/0000-0002-3155-1601)
- Verónica Pena-León
- Concepción María Aguilera (ORCID: https://orcid.org/0000-0002-1451-4788)
- Mar Quiñones (ORCID: https://orcid.org/0000-0003-0180-2147)
- Rosaura Leis (ORCID: https://orcid.org/0000-0002-0540-4210)
- Eva Prida
- María del Valle Palma Villalón
- Javier Costas (ORCID: https://orcid.org/0000-0003-0306-3990)
- Pablo Jácome-Ferrer
- Diego Muñoz-Moreno
Institutions
- Universidad de Granada (ES)
- Universidade de Santiago de Compostela (ES)
- Instituto de Salud Carlos III (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
Publication Details
- Journal
- iScience
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1016/j.isci.2024.111120
- Citations
- 4
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Instituto de Investigación Sanitaria de Santiago de Compostela
- European Commission
- Federación Española de Enfermedades Raras
- Ministerio de Ciencia e Innovación
- Axencia Galega de Innovación
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III