Interleukin 11 therapy causes acute left ventricular dysfunction
Injection of IL11 directly activates IL11RA/JAK/STAT3 in cardiomyocytes to cause acute heart failure. Our data overturn the earlier assumption that IL11 is cardioprotective and explain the serious cardiac side effects associated with IL11 therapy.
Authors
- Konstantinos Vanezis (ORCID: https://orcid.org/0000-0003-0069-0876)
- David Carling (ORCID: https://orcid.org/0000-0002-2316-1830)
- Wei‐Wen Lim (ORCID: https://orcid.org/0000-0003-0311-943X)
- Derek J. Hausenloy (ORCID: https://orcid.org/0000-0003-0729-4956)
- Katie O’Fee
- Anissa A. Widjaja (ORCID: https://orcid.org/0000-0001-9404-7608)
- Paul J.R. Barton (ORCID: https://orcid.org/0000-0002-1165-7767)
- Mark Sweeney
- Chelsie Villanueva-Hayes (ORCID: https://orcid.org/0009-0006-1132-7879)
- Eric L. Lindberg (ORCID: https://orcid.org/0000-0002-2979-433X)
- Henrike Maatz (ORCID: https://orcid.org/0000-0002-9232-6272)
- Norbert Hübner (ORCID: https://orcid.org/0000-0002-1218-6223)
- Chrishan J. A. Ramachandra (ORCID: https://orcid.org/0000-0003-4379-3795)
- Stuart A. Cook (ORCID: https://orcid.org/0000-0001-6628-194X)
- Eneko Pascual-Navarro
- Ivan Andrew (ORCID: https://orcid.org/0000-0003-3310-9937)
- Chung Nga Tam
- Michael S. Lee (ORCID: https://orcid.org/0000-0003-3211-6166)
- Emma Jennings (ORCID: https://orcid.org/0009-0006-0397-2800)
- Ekhlas Rahman
Institutions
- National University of Singapore (SG)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Max Delbrück Center (DE)
- Cardiovascular Institute of the South (US)
- Hammersmith Hospital (GB)
- Harefield Hospital (GB)
- Lung Institute (US)
- German Centre for Cardiovascular Research (DE)
- National Heart Centre Singapore (SG)
- NIHR Wellcome Trust Southampton Clinical Research Facility (GB)
- University College London (GB)
- Imperial College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-10-09
- DOI
- https://doi.org/10.1093/cvr/cvae224
- Citations
- 8
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Ministry of Health
- Wellcome Trust
- Fondation Leducq
- National Institutes of Health
- Medical Research Council
- National Medical Research Council