Interleukin 11 therapy causes acute left ventricular dysfunction

Injection of IL11 directly activates IL11RA/JAK/STAT3 in cardiomyocytes to cause acute heart failure. Our data overturn the earlier assumption that IL11 is cardioprotective and explain the serious cardiac side effects associated with IL11 therapy.

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Publication Details

Journal
Cardiovascular Research
Published
2024-10-09
DOI
https://doi.org/10.1093/cvr/cvae224
Citations
8
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
2.26

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article

Interleukin 11 therapy causes acute left ventricular dysfunction

Konstantinos Vanezis, David Carling, Wei‐Wen Lim, Derek J. Hausenloy et al.
8 citations
Cardiovascular Research
Cytokine Signaling Pathways and Interactions
2.26
article

Interleukin 11 therapy causes acute left ventricular dysfunction

Konstantinos Vanezis, David Carling, Wei‐Wen Lim, Derek J. Hausenloy, Katie O’Fee, Anissa A. Widjaja, Paul J.R. Barton, Mark Sweeney, Chelsie Villanueva-Hayes, Eric L. Lindberg, Henrike Maatz, Norbert Hübner, Chrishan J. A. Ramachandra, Stuart A. Cook, Eneko Pascual-Navarro, Ivan Andrew, Chung Nga Tam, Michael S. Lee, Emma Jennings, Ekhlas Rahman
article en
8 citations

Abstract

Injection of IL11 directly activates IL11RA/JAK/STAT3 in cardiomyocytes to cause acute heart failure. Our data overturn the earlier assumption that IL11 is cardioprotective and explain the serious cardiac side effects associated with IL11 therapy.

Cardiovascular ResearchVol. 120(17)
National University of Singapore (SG), Guy's and St Thomas' NHS Foundation Trust (GB), Max Delbrück Center (DE), Cardiovascular Institute of the South (US), Hammersmith Hospital (GB), Harefield Hospital (GB), Lung Institute (US), German Centre for Cardiovascular Research (DE), National Heart Centre Singapore (SG), NIHR Wellcome Trust Southampton Clinical Research Facility (GB), University College London (GB), Imperial College London (GB), Charité - Universitätsmedizin Berlin (DE)
Ministry of Health, Wellcome Trust, Fondation Leducq, National Institutes of Health, Medical Research Council, National Medical Research Council
Good health and well-being
Openalex Percentile: Top 10%
Cytokine Signaling Pathways and Interactions
2.26
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