Cardiovascular risk according to genetic predisposition to gout, lifestyle and metabolic health across prospective European and Korean cohorts
Our findings indicate that a higher genetic risk of gout is significantly associated with an increased risk of CVD. Moreover, adherence to a favourable lifestyle can significantly reduce CVD risk, particularly in individuals with high genetic risk. These results underscore the potential of PRS-based risk assessment to improve clinical outcomes through tailored preventative strategies.
Authors
- Sang‐Hyuk Jung (ORCID: https://orcid.org/0000-0003-4116-3327)
- Woong‐Yang Park (ORCID: https://orcid.org/0000-0003-4234-0380)
- Hyunsue Do (ORCID: https://orcid.org/0000-0002-9550-1048)
- Hong‐Hee Won (ORCID: https://orcid.org/0000-0001-5719-0552)
- Yonghyun Nam (ORCID: https://orcid.org/0000-0003-2963-2151)
- Ki Won Moon (ORCID: https://orcid.org/0000-0002-4182-8328)
- Chang‐Nam Son (ORCID: https://orcid.org/0000-0002-1722-2190)
- Dokyoon Kim (ORCID: https://orcid.org/0000-0002-4592-9564)
- Jaeyoung Kim (ORCID: https://orcid.org/0000-0001-6983-7907)
- Jae-Seung Yun
Institutions
- Kangwon National University (KR)
- Eulji University (KR)
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- University of Pennsylvania (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- RMD Open
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-004552
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- National Institute of General Medical Sciences